I hate using a mouse. I much prefer to work with the keyboard. I also do a lot of work in a browser. One of the most useful keyboard shortcuts I've come across in Firefox is the apostrophe. If you want to go to a link, simply type ' and start typing the link text. For example, gootodo doesn't have any keyboard shortcuts, but I can create a new todo by typing 'new and hitting enter. That's quicker than moving my hand to the mouse and moving to the link.

You can also go to the detail of a particular todo by typing the todo (if you have the 'Find text as you type' option selected), pressing tab to get to the detail link and hitting enter.